Mitochondrial DNA Damage Does Not Determine C. elegans Lifespan
نویسندگان
چکیده
منابع مشابه
Mitochondrial dynamics and autophagy aid in removal of persistent mitochondrial DNA damage in Caenorhabditis elegans
Mitochondria lack the ability to repair certain helix-distorting lesions that are induced at high levels in mitochondrial DNA (mtDNA) by important environmental genotoxins and endogenous metabolites. These lesions are irreparable and persistent in the short term, but their long-term fate is unknown. We report that removal of such mtDNA damage is detectable by 48 h in Caenorhabditis elegans, and...
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Aphidicolin, a known inhibitor of DNA polymerase a, is a potent inhibitor of nuclear DNA synthesis in HeLa cells but has no effect on the replication f mitochondrial DNA. Parallel experiments with mitochondria incubated in ui tm also show no inhibition of DNA synthesis by aphidicolin; however, DNA synthesis in these isolated mitochondria is completely blocked by dideoxycytidine triphosphate, wh...
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ژورنال
عنوان ژورنال: Frontiers in Genetics
سال: 2019
ISSN: 1664-8021
DOI: 10.3389/fgene.2019.00311